Future prospects for oncolytic therapy

Oncolytic virotherapy for pediatric malignancies: future prospects

Pediatric solid tumors remain a major health concern, with nearly 16,000 children diagnosed each year. Of those, ~2,000 succumb to their disease, and survivors often suffer from lifelong disability secondary to toxic effects of current treatments. Countless multimodality treatment regimens are being explored to make advances against this deadly disease. One targeted treatment approach is oncoly...

Adjunct antimicrobial therapy – prospects for the future

prospects for antifibrotic therapy

antifibrotic therapies should preferentially be targeted to the activated hepatic mesenchymal cells. those cells resemble wound healing myofibroblasts and synthesize an excess of extracellular matrix (ecm) proteins. they derive from quiescent hepatic stellate cells (hsc) and portal/perivascular (myo-) fibroblasts (mf). whereas various agents have been shown to inhibit hsc/mf proliferation and c...

Gene therapy: current status and future prospects.

The ability to successfully introduce foreign genes into eukaryotic cells has made possible a new approach to the treatment of human disease. Gene therapy is now being brought to bear on genetic, malignant, and infectious diseases. In this review, we summarize the status of the field through an analysis of clinical protocols involving transfer of marker or therapeutic gene(s) into various somat...

Phage therapy: past history and future prospects.

Bacterial viruses (bacteriophages, also called "phages") can be robust antibacterial agents in vitro. However, their use as therapeutic agents, during a number of trials from the 1920s to the 1950s, was greatly handicapped by a number of factors. In part, there were certain limitations inherent in phage physiology (e. g. narrow host range, and rapid clearance from the body); in part there were ...